Sep 25 - Dec 19
New ARPA-H External Funding: GIVE: Genetic Medicine and Individualized Manufacturing for Everyone
Extramural Funding
GIVE: Genetic Medicine and Individualized Manufacturing for Everyone
Genetic medicines hold tremendous promise as treatments or preventions for cancer, rare genetic disorders, infections, and other chronic illnesses like autoimmune or cardiovascular diseases. However, they are expensive to manufacture and require centralized equipment, specialized facilities, complex manufacturing optimization, and resource intensive quality control systems. Requirements for ultracold storage and shipping add to the cost and complexity of manufacturing these drug products, especially for personalized and individualized (P/I) genetic medicines. Without innovative manufacturing processes, many products may never advance out of early-stage research and development.
The Genetic Medicines and Individualized Manufacturing for Everyone (GIVE) program aims to enable a multi-site, multi-product, and multi-scale biomanufacturing network. The goal of the program is to develop reliable, simple to use, distributed manufacturing and quality control platforms for genetic medicines. GIVE’s two focus areas include advanced technologies for automated manufacturing and integrated quality control platforms. By bolstering U.S. biomanufacturing technology, GIVE seeks to first-shore P/I genetic medicine manufacturing and improve patient access to cancer therapies, cell therapies, and gene editing technologies.
Key Details:
Genetic medicines hold tremendous promise as treatments or preventions for cancer, rare genetic disorders, infections, and other chronic illnesses like autoimmune or cardiovascular diseases. However, they are expensive to manufacture and require centralized equipment, specialized facilities, complex manufacturing optimization, and resource intensive quality control systems. Requirements for ultracold storage and shipping add to the cost and complexity of manufacturing these drug products, especially for personalized and individualized (P/I) genetic medicines. Without innovative manufacturing processes, many products may never advance out of early-stage research and development.
The Genetic Medicines and Individualized Manufacturing for Everyone (GIVE) program aims to enable a multi-site, multi-product, and multi-scale biomanufacturing network. The goal of the program is to develop reliable, simple to use, distributed manufacturing and quality control platforms for genetic medicines. GIVE’s two focus areas include advanced technologies for automated manufacturing and integrated quality control platforms. By bolstering U.S. biomanufacturing technology, GIVE seeks to first-shore P/I genetic medicine manufacturing and improve patient access to cancer therapies, cell therapies, and gene editing technologies.
Key Details:
- Notice ID: ARPA-H-SOL-25-129
- Solution Summary Due: December 19, 2025 A solution summary is required to submit a full proposal.
- Full Proposal Due: February 27, 2026 Encouraged submissions preferred. Additional details will be provided in a solution summary feedback letter.
- Full RFP: Found HERE.